EN
Li Wan
Organic Chemistry
Associate Professor
Engineering Center of Catalysis and Synthesis for Chiral Molecules Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs
Research Interests
Flow Chemistry, Microreactor
Asymmetric total synthesis of natural products and pharmaceuticals
C-H bond functionalization
Biography
2022.01-NowAssociate Professor, Department of Chemistry, Fudan University
2021.09-2021.12Associate Professor, School of Chemical Engineering, East China University of Science and Technology
2017.10-2021.08Lecturer, School of Chemical Engineering, East China University of Science and Technology
2014.07-2017.09Lecturer, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University
2012.09-2013.09Visiting Ph.D. Student in Organic Chemistry, The Scripps Research Institute (CA)，Advisor: Prof. Jin-Quan Yu
2009.09-2014.06Ph.D. in Applied Chemistry, Nanjing University of Science and Technology, Advisor: Prof. Chun Cai
2005.09-2009.06B.Sc. in Pharmaceutical Engineering, Nanjing University of Science and Technology
Teaching
Organic Synthesis-II
Key Publications
Q. Li, M. J. Liu, Y. J. Zhang, L. Wan,* F. E. Chen.* Scalable and integrated four-step continuous-flow synthesis of ibuprofen using a zinc-catalyzed 1,2-aryl migration strategy. ACS Sustainable Chem. Eng.2024, 12, 8512-8520.
S. Q. Huang, R. Q. Hao, Q. Li, L. Wan,* F. E. Chen.* Selective C–H functionalizations of arenes catalyzed by poly NHC–Pd in flow. React. Chem. Eng.2024, 9, 1641-1645.
Z. N. Li, S. Q. Huang, Y. Tao, M. F. Jiang, D. Cheng, L. Wan,* F. E. Chen.* An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans. React. Chem. Eng.2023, 8, 1882-1887.
L. Wan, M. F. Jiang, D. Cheng, M. J. Liu, F. E. Chen. Continuous flow technology-a tool for safer oxidation chemistry. React. Chem. Eng.2022, 7, 490-550.
L. Zhang, X. F. Bo, H. L. Yao, M. M. Mao, L. Wan,* Z. Xin*. Zinc-catalyzed alkylation of aromatic amines in continuous flow. Org. Process Res. Dev. 2020, 24, 2078-2084.
K. Qiao, D. Zhang, K. Zhang, X. Yuan, M. W. Zheng, T. F. Guo, Z. Fang, L. Wan*, K. Guo*. Iron(II)-catalyzed C-2 cyanomethylation of indoles and pyrroles via direct oxidative crossdehydrogenative coupling with acetonitrile derivatives. Org. Chem. Front.2018, 5, 1129-1134.
L. Wan, K. Qiao, X. Yuan, M. W. Zheng, B. B. Fan, Z. C. Di, D. Zhang, Z. Fang, K. Guo*. Nickel-catalyzed regioselective C-H bond mono- and bis-nitration of aryl oxazolines with TBN as nitro source. Adv. Syn. Cat.2017, 359, 2596-2604.
L. Wan, X. N. Sun, S. J. Shi, J. W. Zhang, X. Li, Z. J. Li, K. Guo*. An efficient synthesis of N-substituted phthalimides using SiO2-tpy-Nb as heterogeneous and reusable catalyst. Catal. Commun.2017, 88, 30-34.
L. Wan, W. T. Zhu, K. Qiao, X. N. Sun, Z. Fang, K. Guo*. C3 Alkylation of indoles catalyzed by carbocations under continuous-flow conditions. Asian J. Org. Chem.2016, 5, 920-926.
G. Li, L. Wan, G. F. Zhang, D. Leow, J. Spangler, J.-Q. Yu. Pd(II)-Catalyzed C−H functionalizations directed by distal weakly coordinating functional groups. J. Am. Chem. Soc.2015, 137, 4391-4397.
L. Wan, N. Dastbaravardeh, G. Li, J.-Q. Yu. Cross-coupling of remote meta-C–H bonds directed by an U-shaped template. J. Am. Chem. Soc.2013, 135, 18056-18059.
G. Li, D. Leow, L. Wan, J.-Q. Yu. Ether-directed ortho-C–H olefination with a palladium(II)/monoproctected amino acid catalyst. Angew. Chem., Int. Ed. 2013, 52, 1245-1247.
